Immunology Refresher

Immune System

A coordinated system of cells, tissues, and soluble molecules that constitute the body's defense against invasion by nonself entities, including infectious and inert agents and tumor cells.1

The immune system has 4 key tasks2:

1. Recognition: Detect infection or harm
2. Effector function: Contain and eliminate infection
3. Regulation: Control activity to avoid damage to the body
4. Memory: Remember exposure; react immediately and strongly upon re-exposure

Innate and Adaptive Immunity2

Immune System

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Understanding JAK Pathways

Discover more about JAK pathways and how they are related to inflammatory and autoimmune diseases such as rheumatoid arthritis (RA).


Behind the Science

Watch leading scientists discuss the JAK pathways.

1. Mak TW, Saunders ME. The Immune Response: Basic and Clinical Principles. Burlington, MA: Elsevier Academic Press; 2006:1144.
2. Murphy K, Travers P, Walport M. Janeway's Immuno Biology. 7th ed. New York, NY: Garland Science, Taylor & Francis Group, LLC; 2008.
3. McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007;7(6):429-442.